Alzheimer’s Disease — A Sudden Flash of Genius Rudy Tanzi

Excerpt from a blog by Alzheimer’s Reading Room:

Rudy Tanzi is a professor of neurology and director of the genetics and aging unit at Massachusetts General Hospital. After having a beer with his buddies, Dr. Tanzi went back to his office and looked at his list of genes associated with Alzheimer’s disease. He noticed that many of the genes looked like genes associated with the so-called innate immune system. He walked into the office of his colleague Robert Moir and mentioned this to him. Moir then handed Tanzi a spreadsheet, it was a comparison of A-beta and a well-known protein of the innate immune system, LL-37. They looked very similar.

I’ll spare you the long scientific explanation. Bottom line, they did a whole bunch of tests and came up with a new and different way of looking at amyloid beta and possible treatments for Alzheimer’s disease.

His hypothesis is that A-beta may be part of the brain’s normal defenses against invading bacteria and other microbes. Why is this important? It raises question about treatments that are designed to eliminate A-beta from the brain.

To read more click:


About UWF Center on Aging

The Center on Aging at the University of West Florida was established in the Fall of 2010 when the School of Psychological and Behavioral Sciences faculty along with assistance from Sponsored Research submitted a grant to the State University System Board of Governors in support of aging initiatives for Northwest Florida. Its mission is to improve the quality of life of aging adults through the application of science to address challenges associated with aging and to promote healthy aging, with an emphasis on prevention. This will be accomplished through inter-disciplinary and inter-professional efforts of basic and applied research, consultation, and partnerships with community agencies. Education and training, direct services to the aging population, and public awareness and understanding of the contributions and needs of elders will be primary objectives.
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